Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
Kawssar Harb, Elia Magrinelli ... Christian Alfano
Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.
Meningeal lymphatic vessels are present in human and nonhuman primates (common marmoset monkeys) and they can be noninvasively imaged and mapped in vivo with high-resolution, clinical MRI.
Yishan Sun, Sergiu P Paşca ... Ricardo E Dolmetsch
A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
Eric Engelbrecht, Michel V Levesque ... Timothy Hla
The sphingosine 1-phosphate receptor-1 (S1PR1) signals in heterogenous populations of mouse adventitial lymphatic (LEC) and arterial endothelial cells (aEC1, aEC2) to regulate chromatin and the transcriptome, thus affecting their phenotypes.
Benjamin Schwarz, Dominik Hollfelder ... Ingolf Reim
A novel regulatory model for the diversification of cardiac cell subpopulations in Drosophila is established by linking epidermal growth factor signaling with differential activities of key transcription factors.
Diek W Wheeler, Charise M White ... Giorgio A Ascoli
Hippocampome.org is an online resource that provides free human- and machine-readable access to the comprehensive property-based classification of hippocampal neurons from 14,000 pieces of published experimental evidence.
Comparative studies of gene expression in the uterus during pregnancy identifies new genes important for pregnancy and associated with complications such as preterm birth.