541 results found
    1. Immunology and Inflammation
    2. Medicine

    Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

    Jack Gisby et al.
    Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.
    1. Microbiology and Infectious Disease

    Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

    Michaela Gregorova et al.
    Post-acute or long-COVID is associated with bystander T-cell activation and a recurring antimicrobial resistant, bacterial ventilator-associated pneumonia.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke et al.
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
  1. COVID-19 and the Research Community: Struggling to get started

    Andy Tay
    As the world attempts to cope with the devastating impact of the COVID-19 pandemic, researchers about to start PhDs and postdocs face particular challenges.
  2. COVID-19 and the Research Community: Being vulnerable

    Jasper Elan Hunt
    Early-career researchers feel discouraged from exposing vulnerability even during a global crisis.
  3. COVID-19 and the Research Community: The challenges of lockdown for early-career researchers

    Nicola Byrom
    Thousands of UK doctoral students and early-career researchers shared the repercussions of lockdown on their work and wellbeing.
  4. Point of View: Mitigating the impact of conference and travel cancellations on researchers’ futures

    Tracey Weissgerber et al.
    As the scientific community adapts to new working conditions in response to the growing pandemic, early-career researchers recommend actions to help lessen the unintended consequences of canceled conferences.
    1. Epidemiology and Global Health

    Antimicrobial resistance and COVID-19: Intersections and implications

    Gwenan M Knight et al.
    COVID-19 will have an ongoing impact on antimicrobial resistance acquisition, transmission, and burden, requiring the close attention of researchers globally to generate a complete evidence base for the shifted dynamics.
    1. Neuroscience

    Transsynaptic mapping of Drosophila mushroom body output neurons

    Kristin M Scaplen et al.
    Transsynaptic mapping of the postsynaptic connections of mushroom body output neurons reveal both divergent and convergent projections allowing for multimodal integration prior to initiation of an output response.
    1. Immunology and Inflammation

    Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

    Juan L Mendoza et al.
    Potential for specific microbiome-directed, MHC-restricted shaping of a commonly selected HIV-specific CD8+ T cell population was suggested by MHC class I yeast display-based peptide screening approaches.

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