1,412 results found
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi et al.
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Neuroscience

    GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

    Jenna Nagy et al.
    Elimination of GABAA receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo et al.
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost et al.
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
    1. Cell Biology

    A robust method for particulate detection of a genetic tag for 3D electron microscopy

    James Rae et al.
    Development of a new system for gold particle detection of a genetic tag for electron microscopy.
    1. Developmental Biology

    Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

    Sounak Sahu et al.
    Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
    1. Cell Biology

    SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

    David W Sanders et al.
    A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.
    1. Neuroscience

    fMRI-based detection of alertness predicts behavioral response variability

    Sarah E Goodale et al.
    Time-varying states of alertness that shape behavioral responses may be detected from fMRI signal patterns.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Neuroscience

    Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

    Alexander Fengler et al.
    A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.

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