A single protein catalyzes site-specific DNA recombination upon blue-light illumination.

Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.

Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.

HIV-1 Vpr antagonises innate immune sensing of viral and non-viral stimuli by preventing activated IRF3 and NF-κB nuclear transport.

Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.

Targeting aberrant CRTC-CREB activation blocks the growth of LKB1-inactivated lung cancer.

The activation of small-conductance calcium-activated potassium channels in spines by action potentials regulates the induction of spike-timing dependent synaptic plasticity during low-frequency single action potential–EPSP pairing.

Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.

The retina compensates for rod death and deteriorating cones to retain high-fidelity visual signaling to the brain.

A conceptually simple algorithm can analyze previously uncharacterized 2D coiled postures of the nematode C. elegans and has uncovered new reorientation behaviors in large amplitude turns.