2,059 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin et al.
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Immunology and Inflammation

    Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

    Ricardo A Fernandes et al.
    Surrogate agonist peptide ligands discovered through screening of an IAb-peptide library potentiate expansion of visceral adipose tissue resident regulatory T cells and protect mice from inflammation and improve metabolic indices.
    1. Cancer Biology

    Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

    Xin Zhou et al.
    Targeting aberrant CRTC-CREB activation blocks the growth of LKB1-inactivated lung cancer.
    1. Immunology and Inflammation

    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

    Xiaomei Yuan et al.
    Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

    Lloyd Davis et al.
    A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
    1. Neuroscience

    CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

    Xiao-Wen Yu et al.
    Behavioral, biochemical, and biophysical analyses show that age-related memory deficits can be rescued by directly overexpressing wild-type CREB.
    1. Neuroscience

    Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

    Edward Pym et al.
    Changes in Shank gene dosage alter voltage-activated calcium current and calcium-activated gene expression in a manner that parallels the effects of human Shank copy number variation on psychiatric disease risk.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

    Mark David Hayes et al.
    Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.

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