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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

    Xu Zheng, Shi Yu ... Guangxun Meng
    Interleukin-1 activates RhoA/ROCK signaling, which drives the enrichment of actin bundles at the cell-cell junctions, preventing SARS-CoV-2 spreading via syncytia formation.
    1. Biochemistry and Chemical Biology

    Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    Parnian Arafi, Sujan Devkota ... Michael S Wolfe
    Further evidence in support of a new amyloid-independent hypothesis for the pathogenesis of Alzheimer's disease is provided, with an expanded set of Alzheimer-causing mutations in the protease that produces amyloid.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Neuroscience

    Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology

    Discovering Root Causal Genes with High Throughput Perturbations

    Eric V Strobl, Eric R Gamazon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest

    Dhaval Ghone, Edward L Evans ... Aussie Suzuki
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia

    Takuma Nohara, Junichi Kumamoto ... Ken Natsuga
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine

    Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Guillaume Martinez ... Jessica Escoffier
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
    1. Microbiology and Infectious Disease

    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Louise Tzung-Harn Hsieh, Belinda S Hall ... Rachel E Simmonds
    The secreted toxin mycolactone has severe effects on the cells lining blood vessels that will play a critical role in the development of swelling in Buruli ulcer disease.
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
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