1,316 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

    Steven Lin et al.
    Building on previous work (Jinek et al., 2013), we report a simple and robust system to achieve high fidelity and high efficiency (30% of homologous recombination) genome engineering by homology-directed repair pathway in human cells using cell cycle synchronization and timed delivery of Cas9 ribonucleoprotein complexes.
    1. Cell Biology

    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells

    Jaroslaw Cendrowski et al.
    Erythroid-enriched BMP2K kinase, in addition to its predicted function in endocytosis, regulates distribution and abundance of COPII assemblies and autophagic degradation through opposing actions of its two splicing variants.
    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

    Anna Caballe et al.
    ULK3 is a kinase in the abscission checkpoint that temporarily inactivates ESCRT-III proteins via phosphorylation, which is required to delay cytokinesis in response to defects in mitosis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis et al.
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Developmental Biology

    Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

    Irepan Salvador-Martínez et al.
    Computer simulations reveal the potential and limitations of recently proposed CRISPR-based cell lineage recorders, and suggest how the recorders' design can be optimised to yield more accurate cell lineage trees.
    1. Genetics and Genomics
    2. Neuroscience

    CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Eric Deneault et al.
    Autism-associated iPSC-derived neurons mutant in CNTN5 or EHMT2 are hyperactive.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Cancer-associated TERT promoter mutations abrogate telomerase silencing

    Kunitoshi Chiba et al.
    TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.
  1. Meta-Research: Gender variations in citation distributions in medicine are very small and due to self-citation and journal prestige

    Jens Peter Andersen et al.
    In studies of gender disparities in academia, increased focus is required on within-group variability and between-group overlap of distributions when interpreting and reporting results.
    1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao et al.
    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.

Refine your results by:

Type
Research categories