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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush, Daniel C Diaz ... Tatjana Piotrowski
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Genetics and Genomics
    2. Neuroscience

    A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

    Gha-Hyun J Kim, Han Mo ... Su Guo
    In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
    1. Developmental Biology
    2. Genetics and Genomics

    Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

    Elizabeth A Bearce, Zoe H Irons ... Daniel T Grimes
    Urp1 and Urp2 peptides, expressed in CSF-contacting neurons in the spinal canal, prevent abnormal curvature of the zebrafish spine.
    1. Stem Cells and Regenerative Medicine

    ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

    Richard H Chapple, Tianyuan Hu ... Daisuke Nakada
    Estrogen is a systemic factor that promotes hematopoietic regeneration by activating the unfolded protein responses.
    1. Cell Biology

    Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair

    Danny LeBert, Jayne M Squirrell ... Anna Huttenlocher
    Live real time imaging and perturbation experiments reveal how vimentin integrates with early damage induced reactive oxygen species to mediate collagen rearrangements and epithelial cell projections during wound repair and regeneration.
    1. Developmental Biology

    Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

    Yan-Xue Li, Xin-Le Kang ... Xiao-Fan Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Ecology

    The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sucrose

    Shuai-Shuai Zhang, Pei-Chao Wang ... Chen-Zhu Wang
    The sweet taste receptors in the cotton bollworm (Helicoverpa armigera) are evolved to adapt towards the larval and adult foods with different types and amounts of sugar.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1

    Juan Xiang, Chaoyang Fan ... Pei Xu
    An inducible two-component CRISPR-based platform that rapidly repositions HSV-1 genomes to the nuclear edge unveils intranuclear space heterogeneity for the incoming viral genomes and dynamic stages of the host-virus interplay during early infection.
    1. Developmental Biology

    FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

    Yuki Kaneda, Haruhiko Miyata ... Masahito Ikawa
    FBXO24, a testis-enriched E3 ubiquitin ligase, is essential for sperm flagellum formation and male fertility in mice.
    1. Cell Biology
    2. Neuroscience

    Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

    Victor C Wong, Patrick R Houlihan ... Erin K O'Shea
    Glutamate receptor-containing vesicles are positioned in the dendritic shaft near sites of synaptic activity by F-actin.