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    1. Neuroscience

    State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

    Aurélie Pala, Carl CH Petersen
    Membrane potential recordings in awake mice from two genetically defined classes of neocortical inhibitory neurons reveal their distinct patterns of activity and unitary excitatory synaptic inputs, which are differentially modulated by behavior and local network activity.
    1. Microbiology and Infectious Disease

    A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

    Manabu Aoki et al.
    GRL-142 is an HIV protease inhibitor with a unique structure and atto-to-picomolar potency against a wide range of HIV strains.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

    Ben F Brian IV et al.
    The ubiquitin ligase c-Cbl preferentially targets unique-region phosphorylated LynA for rapid degradation, regulating its expression and differentially tuning signaling responsiveness in macrophages and mast cells.
    1. Neuroscience

    Cre-assisted fine-mapping of neural circuits using orthogonal split inteins

    Haojiang Luan et al.
    A genetic method allows neurons to be individually identified and characterized by combining information about both their developmental origins and their mature patterns of gene expression.
    1. Cancer Biology
    2. Immunology and Inflammation

    Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Biancamaria Ricci et al.
    Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.
    1. Structural Biology and Molecular Biophysics

    Architectural principles for Hfq/Crc-mediated regulation of gene expression

    Xue Yuan Pei et al.
    Structural insights show how RNA chaperones cooperate to recognise defined target transcripts and suppress gene expression.
    1. Neuroscience

    A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

    David Goyer et al.
    VIP neurons are a novel class of inferior colliculus stellate neurons that project to long-range auditory and non-auditory targets and integrate inputs from the auditory brainstem and contralateral IC.
    1. Neuroscience

    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

    Nicole Scholz et al.
    Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch

    Kotaro Sugimoto et al.
    A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

    Misty R Jenkins et al.
    Inhibition of the catalytic activity of the Zap70 kinase reveals that discrete TCR-regulated events control the remodelling of the actin cytoskeleton when the cytotoxic T cell interacts with its target.