4,298 results found
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

    Andrew R Conery et al.
    CBP/EP300 bromodomain inhibitors have a therapeutic application in oncology via targeting the IRF4 transcriptional program, a clinically validated network critical for multiple myeloma cell viability.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry et al.
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Structural Biology and Molecular Biophysics

    Structural model for differential cap maturation at growing microtubule ends

    Juan Estévez-Gallego et al.
    The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin et al.
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Chromosomes and Gene Expression

    Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

    Juncao Xu et al.
    The cryo-EM structure of Escherichia coli Crl–TAC reveals the mechanism of DNA-contact-independent transcription activation.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez et al.
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Plant Biology

    A novel role for the root cap in phosphate uptake and homeostasis

    Satomi Kanno et al.
    Real-time 33P imaging combined with specific complementation of inorganic phosphate transport in the root cap reveals this tissue’s contribution to phosphate uptake.
    1. Neuroscience

    Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

    Line S Löken et al.
    Although primary sensory neuron-derived calcitonin gene-related peptide (CGRP) contributes to the processing of pain messages, an understudied population of dorsal horn CGRP-expressing interneurons also contributes to the processing of mechanical sensitivity.
    1. Genetics and Genomics

    Expansion of the circadian transcriptome in Brassica rapa and genome-wide diversification of paralog expression patterns

    Kathleen Greenham et al.
    Whole genome duplication in Brassica rapa is accompanied by both expansion of the circadian transcriptome and widespread temporal reconfiguration of gene regulatory networks consistent with subfunctionalization among pairs of paralogs.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.

Refine your results by:

Type
Research categories