2,957 results found
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez et al.
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Plant Biology

    A novel role for the root cap in phosphate uptake and homeostasis

    Satomi Kanno et al.
    Real-time 33P imaging combined with specific complementation of inorganic phosphate transport in the root cap reveals this tissue’s contribution to phosphate uptake.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

    Andrew R Conery et al.
    CBP/EP300 bromodomain inhibitors have a therapeutic application in oncology via targeting the IRF4 transcriptional program, a clinically validated network critical for multiple myeloma cell viability.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

    Roni M Lahr et al.
    La-related protein 1 specifically and directly binds the 5' cap and first nucleotide of mRNAs encoding ribosomal proteins and translation factors, inhibiting the assembly of translation initiation factors on these messages and therefore their translation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry et al.
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Developmental Biology
    2. Neuroscience

    Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

    Stephan Heermann et al.
    The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor et al.
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Developmental Biology
    2. Genetics and Genomics

    CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity

    Xiang-Ru Shannon Xu et al.
    Dissection of a cis-regulatory element (CRM) in its native chromosomal context using CRISPR/Cas9 editing and novel 'Active Genetics' reveals new features of CRM function and insights into how such regulatory elements change during evolution.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins et al.
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The size of the EB cap determines instantaneous microtubule stability

    Christian Duellberg et al.
    The EB binding region defines the length of the protective cap that stabilizes growing microtubules.

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