1,903 results found
    1. Chromosomes and Gene Expression

    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

    Amy E Campbell et al.
    CRISPR/Cas9 engineered locus-specific proteomics leads to the identification of NuRD, CAF-1, and MBD3L2 as regulators of the early embryonic transcription factor DUX4.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

    Thornton W Thompson et al.
    Macrophages respond to elevated levels of CSF-1 in tumor micro-environments by expressing a ligand for the NKG2D immunoreceptor.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz et al.
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones

    Wallace H Liu et al.
    Biophysical and biochemical approaches reveal new insights into the architecture of CAF-1 and the unique mechanism by which CAF-1 tetramerizes histones H3/H4.
    1. Immunology and Inflammation

    ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation

    Claire Pearson et al.
    Innate lymphoid cells, which are dynamic under steady-state conditions, respond to a colitogenic stimulus by mobilizing from cryptopatches and secreting GM-CSF to organize the pro-inflammatory response.
    1. Immunology and Inflammation

    Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response

    Zhou Yu et al.
    By joining the Skp1-Cul1-Rbx1 SCF complex, Fbxo21 interacts with ASK1 and mediates Lys29-linkage of ASK1, leading to type I IFN production.
    1. Human Biology and Medicine
    2. Neuroscience

    Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

    Ian F Harrison et al.
    The first non-invasive technique to assess the action of brain clearance mechanisms, driven by the perivascular inflow of cerebrospinal fluid, has been developed using magnetic resonance imaging.
    1. Chromosomes and Gene Expression

    Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

    Xuan Li, Jessica K Tyler
    The human genome is unpackaged to allow DNA breaks to be joined back together, and then repackaged into chromosomes afterwards.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

    Marcello Clerici et al.
    Structural, biochemical, and proteomic analyses of a four-subunit core module of the cleavage and polyadenylation specificity factor complex reveal its molecular architecture and specific determinants of polyadenylation signal recognition in human mRNAs.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication

    Francesca Mattiroli et al.
    After DNA replication, nucleosomes are assembled by two histone chaperone complexes each bound to an H3-H4 histone dimer, suggesting the feasibility for a semi-conservative mode of epigenome inheritance.

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