1,955 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry et al.
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Chromosomes and Gene Expression

    Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor

    Juncao Xu et al.
    The cryo-EM structure of Escherichia coli Crl–TAC reveals the mechanism of DNA-contact-independent transcription activation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells

    Jing-Ping Hsin et al.
    Phosphorylation of tyrosine 1 in the carboxy-terminal domain (CTD) of the largest subunit of RNA Polymerase (RNAP) II functions to stabilize this domain, and facilitates turnover of upstream antisense RNAs.
    1. Cell Biology
    2. Human Biology and Medicine

    Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

    Xiaoxiao Li et al.
    Orphan nuclear receptor Nur77 protects bone by enabling a timely termination of osteoclast differentiation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases

    Sofia Battaglia et al.
    In vivo and in vitro elongation factor-RNA interaction data provide a missing link in understanding how processive elongation complexes are formed on active genes and disassembled at the end of genes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

    Fabienne Lampert et al.
    Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.
    1. Chromosomes and Gene Expression

    Promoter nucleosome dynamics regulated by signalling through the CTD code

    Philippe Materne et al.
    Phosphorylation of the C-terminal domain (CTD) of RNA Polymerase II controls nucleosomes dynamics at specific promoters to regulate transcription.
    1. Chromosomes and Gene Expression

    Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells

    Nicolas Descostes et al.
    Genome-wide analysis reveals novel functions for a post-translational modification to the carboxy-terminal domain (CTD) of RNA Polymerase II in mammals.
    1. Plant Biology

    ATP sensing in living plant cells reveals tissue gradients and stress dynamics of energy physiology

    Valentina De Col et al.
    The monitoring of ATP dynamics in living plants using fluorescent protein biosensor provides evidence for the complex relationship between cellular energy status and growth.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

    Ben F Brian IV et al.
    The ubiquitin ligase c-Cbl preferentially targets unique-region phosphorylated LynA for rapid degradation, regulating its expression and differentially tuning signaling responsiveness in macrophages and mast cells.

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