194 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

    Deike J Omnus et al.
    A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.
    1. Cancer Biology

    Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

    Teresa WM Fan et al.
    Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
    1. Neuroscience

    Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

    Anita E Autry et al.
    Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
    1. Chromosomes and Gene Expression

    SUV39 SET domains mediate crosstalk of heterochromatic histone marks

    Alessandro Stirpe et al.
    Clr4, a highly conserved SUV39 histone methyltransferase, requires its SET domain to sense histone H3K14 ubiquitination in order to maintain heterochromatin and H3K9 methylation.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Cell Biology

    A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

    Xiao Zhang et al.
    A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age and in states of metabolic stress.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

    Isabelle J Marié et al.
    Overlapping action of type I, II, and III interferons maintains microbiome homeostasis, prevents IL-17-driven myeloproliferative disease, and protects against inflammatory bowel disease.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter et al.
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Cell Biology

    CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels

    André Brás Gonçalves et al.
    Analysis of mutant cells combined with biochemical experiments reveals that CEP78 is recruited to the centrosome by CEP350 and regulates ciliogenesis and ciliary length control through CP110-dependent and CP110-independent mechanisms, respectively.

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