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Therapeutic potential of CCL3 for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement.

Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.

High-throughput phenotypic screening followed by unbiased target identification reveals a new molecular glue HQ461 that induces CDK12-DDB1 interaction to promote degradation of Cyclin K via the ubiquitin proteasome system.

A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.

In depth phenotyping from tissues and in vitro activation studies reveal antiviral function of MAIT cells- with particular emphasis on HIV infection.

By joining the Skp1-Cul1-Rbx1 SCF complex, Fbxo21 interacts with ASK1 and mediates Lys29-linkage of ASK1, leading to type I IFN production.

A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.

Contrary to the generally accepted model, condensin maintains proper gene expression by promoting the accurate segregation of chromosomes and the partitioning of the RNA-exosome throughout mitosis, instead of directly regulating transcription.

The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.

Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.