237 results found
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Neuroscience

    Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

    Narendra Mukherjee et al.
    Primary taste cortex does far more than code tastes by turning taste codes into motor commands via population dynamics.
    1. Cell Biology

    The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

    Danielle DiTirro et al.
    A Tubby protein regulates ciliary membrane morphology and phosphoinositide composition in a context-dependent manner.
    1. Microbiology and Infectious Disease

    Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

    Catherine R Armbruster et al.
    Subpopulations of polysaccharide producer and surface explorer cells play specialized roles in early Pseudomonas aeruginosa biofilm formation.
    1. Cell Biology
    2. Developmental Biology

    Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

    Péter Lőrincz et al.
    Recruitment of HOPS tethering complex to target membranes to promote vesicle fusions requires proper complex assembly and specific small GTPases, and HOPS is not transformed from the related miniCORVET complex.
    1. Neuroscience

    Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors

    Justin J Grassmeyer et al.
    The vesicular Ca2+ sensor synaptotagmin-1 regulates both fast phasic and slow tonic glutamate release at ribbon synapses of rod and cone photoreceptor cells.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Ion counting demonstrates a high electrostatic field generated by the nucleosome

    Magdalena Gebala et al.
    First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational switches control early maturation of the eukaryotic small ribosomal subunit

    Mirjam Hunziker et al.
    Mass spectrometry analysis of purified pre-ribosomal RNAs shows that stable ribosomal RNA domains independently recruit assembly factors, and the cryo-EM structure of the 5' ETS ribonucleoprotein reveals regulatory conformational switches.
    1. Microbiology and Infectious Disease

    Species specific differences in use of ANP32 proteins by influenza A virus

    Jason S Long et al.
    Chicken ANP32A, and not chicken ANP32B, supports influenza polymerase activity and thus editing of this single gene may generate chickens that are resilient to influenza virus infection.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    'Palaeoshellomics’ reveals the use of freshwater mother-of-pearl in prehistory

    Jorune Sakalauskaite et al.
    Ancient proteomes from tiny shell ornaments were successfully characterised for the first time, showing the unexpected use of mother-of-pearl from local riverine molluscs in both coastal and inland prehistoric sites.

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