243 results found
    1. Neuroscience

    Consolidation alters motor sequence-specific distributed representations

    Basile Pinsard et al.
    The consolidation of newly acquired motor skills induces a functional reorganization of sequential information representations within secondary motor cortex, basal ganglia and hippocampus.
    1. Neuroscience

    Decoupling sensory from decisional choice biases in perceptual decision making

    Daniel Linares et al.
    Perceptual decision making, even in simple scenarios, is affected by sensory and decisional choice biases.
    1. Developmental Biology
    2. Neuroscience

    Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

    Hirofumi Noguchi et al.
    Sufu controls dentate gyrus stem cell quiescence by acting as a positive regulator of Shh signaling and loss of Sufu leads to dramatic failure to produce sufficient quiescent stem cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

    Zachary F Hallberg et al.
    A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic et al.
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Neuroscience

    Across-species differences in pitch perception are consistent with differences in cochlear filtering

    Kerry MM Walker et al.
    Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

    Lucas Tafur et al.
    Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg et al.
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Genetics and Genomics

    Environmentally-induced epigenetic conversion of a piRNA cluster

    Karine Casier et al.
    Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
    1. Neuroscience

    Neural structure mapping in human probabilistic reward learning

    Fabrice Luyckx et al.
    During learning, human neural codes for experienced reward probability map onto the same mental number line for symbolic numbers.

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