20 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic, Bennett William Fox ... Erik C Andersen
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Microbiology and Infectious Disease

    Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

    Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
    A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
    1. Neuroscience

    Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton

    Csaba Verasztó, Martin Gühmann ... Gáspár Jékely
    In a zooplankton larva, ciliary and rhabdomeric photoreceptor cells work antagonistically to form a spectral depth gauge.
    1. Neuroscience
    2. Physics of Living Systems

    Continuous odor profile monitoring to study olfactory navigation in small animals

    Kevin S Chen, Rui Wu ... Andrew M Leifer
    To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Neuroscience

    Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

    Shenqin Yao, Joseph Bergan ... Catherine Dulac
    Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
    1. Neuroscience

    Information, certainty, and learning

    Justin A Harris, CR Gallistel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams, Mary M Conte ... Nicholas D Schiff
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr, Divya A Shiroor, Carolyn E Adler
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies, Kai Lei ... Alejandro Sánchez Alvarado
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.

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