Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.

The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.

A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.

A cell-free system combined with cell-based assays elucidate the biochemical mechanism of signal transduction mediated by the mitochondrial protein MAVS and delineates the role of ubiquitin E3 ligases in antiviral innate immune responses.

The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.

The anti-diabetic drug metformin, currently in clinical trials as a potential anti-cancer agent, reduces tumor growth by inhibiting mitochondrial complex I of human cancer cells.

A novel master regulatory mechanism of cell proliferation and senscence employs the lncRNA UCA1 and a CAPERα/TBX3 corepressor.

Developing long bones contain distinct mesenchymal stem-cell populations derived from mesoderm and neural crest, which have specialized functions in skeleton formation and the establishment of the hematopoietic stem-cell niche, respectively.

The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.

In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.