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    1. Developmental Biology

    Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

    Di Peng, Koji Ando ... Katarzyna Koltowska
    Spatio-temporal analysis using live imaging in zebrafish reveals mural cells as a source of pro-lymphangiogenic factors including chemokine and growth factor signalling, necessary for robust lymphatic endothelial cell migration and survival.
    1. Immunology and Inflammation
    2. Medicine

    Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

    Zicheng Hu, Kattria van der Ploeg ... Prasanna Jagannathan
    Immune markers measured at the early stage of COVID-19 infection are associated with various clinical outcomes and can be used to predict disease progression, T cell memory, viral shedding, and the antibody response of the COVID-19 patients.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Cytotoxic T cells swarm by homotypic chemokine signalling

    Jorge Luis Galeano Niño, Sophie V Pageon ... Maté Biro
    Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CCL28 modulates neutrophil responses during infection with mucosal pathogens

    Gregory T Walker, Araceli Perez-Lopez ... Manuela Raffatellu
    Chemokine CCL28 plays a key role in shaping neutrophil responses during intestinal Salmonella infection and lung Acinetobacter infection.
    1. Cell Biology

    A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

    Qin Zou, Rong Yuan ... Yanzhi Jiang
    The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
    1. Developmental Biology

    Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo

    Dana Meyen, Katsiaryna Tarbashevich ... Erez Raz
    Functional analysis of filopodia by specific interference with their formation and distribution reveals a critical role in conferring intracellular polarity and in controlling the dynamic properties of chemokine-guided cell migration in vivo.
    1. Neuroscience

    CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility

    Lindsay K Festa, Elena Irollo ... Olimpia Meucci
    Unveiling a novel role of the chemokine CXCL12 in the mature brain that opens up new lines of investigation for the development of therapeutics against cognitive impairment.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind, Xinxia Zhu ... Daniel L Marks
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cell Biology
    2. Immunology and Inflammation

    Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

    Ana J Caetano, Yushi Redhead ... Paul T Sharpe
    Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
    1. Cell Biology
    2. Medicine

    Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

    Srinu Tumpara, Matthias Ballmaier ... Sabina Janciauskiene
    Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.