An optogenetic dual-color Ca²⁺-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca²⁺ signaling.

The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.

An unbiased genetic screen in Drosophila provides evidence for a direct link between glial Ca2+ 25 signaling and classical functions of glia in buffering external K+ as a mechanism to regulate neuronal excitability.

R-spondins 2 and 3 can potentiate WNT signaling in the absence of LGRs through interactions with ZNRF3/RNF43 E3 ubiquitin ligases and heparan sulfate proteoglycans, defining two alternative modes of R-spondin-mediated signaling.

Zebrafish sperm display an unusual pathway for Ca²⁺ signalling.

Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca²⁺ signaling pathway maintaining the quiescent state.

Zinc metalloproteinase Papp-aa-mediated Igfbp5 proteolysis functions as a [Ca²⁺]-regulated molecular switch linking IGF signaling to epithelial cell proliferation and bone calcification.

A new component, CatSper zeta, is required for continuous alignment of the calcium channel along the sperm's tail and is crucial for normal sperm swimming behavior and fertility.

Gene knockdown experiments in fruit fly pupae reveal the role of the signaling molecule 'dFrizzled2' in the development of a neural circuit that helps insects to fly continuously for extended periods.

The transformation of fruit fly larvae into pupae provides insights into the processes that enable animals to survive periods of food shortage.