Multivariate analysis of respiratory cycle shows that GABAergic disinhibition in the rostral regions of the lateral parafacial area is linked to the most significant and enduring changes in active expiration.
Raeann Goering, Laura I Hudish ... J Matthew Taliaferro
The molecular determinants for neuronal subcellular RNA transport by FMRP are defined, with interactions between RNA G-quadruplexes and the RGG domain of FMRP being of critical importance.
Adlin Abramian, Rein I Hoogstraaten ... Matthijs Verhage
Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.
Dominic Gonschorek, Matías A Goldin ... Thomas Euler
Nitric oxide is a type-selective neuromodulator affecting the temporal, but not the spatial response kinetics of a specific subset of mouse retinal ganglion cells.
Justin D Lormand, Soo-Kyoung Kim ... Holger Sondermann
Dinucleases, specialized enzymes that catalyze the final step in RNA degradation, have evolved independently and repeatedly to fulfill essential roles in cell growth.
Hannah R Monday, Mathieu Bourdenx ... Pablo E Castillo
CB1-receptor-mediated inhibitory long-term depression (LTD) relies on both protein synthesis and ubiquitination to elicit structural changes that underlie long-term reduction of GABA release.
Kirsty J McMillan, Paul J Banks ... Peter J Cullen
An unbiased proteomic approach identifies a new regulator of AMPA receptor trafficking providing additional insight into synaptic transmission and plasticity.
Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.