2,250 results found
    1. Neuroscience

    The number of olfactory stimuli that humans can discriminate is still unknown

    Richard C Gerkin, Jason B Castro
    The recent claim that humans can discriminate more than one trillion odors is shown to be unwarranted.
    1. Neuroscience

    Neuronal processing of noxious thermal stimuli mediated by dendritic Ca2+ influx in Drosophila somatosensory neurons

    Shin-Ichiro Terada et al.
    Drosophila polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca2+ influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya et al.
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
    1. Neuroscience

    Keratinocytes can modulate and directly initiate nociceptive responses

    Kyle M Baumbauer et al.
    Optogenetics reveals that keratinocytes can evoke action potential firing in several types of cutaneous sensory afferents, including those that transmit thermal, mechanical and pain stimuli.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

    Feng Zhang et al.
    TRPV channels share general mechanisms of activation while exhibiting subtype-specific features along the activation pathway that can determine their apparent sensitivity to stimuli.
    1. Neuroscience

    Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila

    Alessia Soldano et al.
    Fruit flies can taste and avoid food contaminated with a bacterial toxin using the same channel protein that functions in humans as sensor of noxious chemical stimuli.
    1. Neuroscience

    Encoding sensory and motor patterns as time-invariant trajectories in recurrent neural networks

    Vishwa Goudar, Dean V Buonomano
    A recurrent network model trained to transcribe temporally scaled spoken digits into handwritten digits proposes that the brain flexibly encodes time-varying stimuli as neural trajectories that can be traversed at different speeds.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter et al.
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Neuroscience

    Pan-neuronal screening in Caenorhabditis elegans reveals asymmetric dynamics of AWC neurons is critical for thermal avoidance behavior

    Ippei Kotera et al.
    Functional screening of the entire neuronal network of C. elegans in response to specific stimuli can discover new neural behavior.
    1. Neuroscience

    Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons

    Koun Onodera et al.
    Drosophila nociceptive neurons convert high-intensity stimuli into characteristic fluctuations of firing rates, quiescent periods of which are regulated by hyperpolarization through small conductance Ca2+-activated K+ channels.

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