252 results found
    1. Developmental Biology
    2. Neuroscience

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal et al.
    CaMKI and neuroendocrine signaling integrate information about food status to regulate a developmental decision in C. elegans.
    1. Computational and Systems Biology
    2. Neuroscience

    Subunit exchange enhances information retention by CaMKII in dendritic spines

    Dilawar Singh, Upinder Singh Bhalla
    Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16

    Li Tao et al.
    Longevity in C. elegans is influenced not only by insulin/IGF-1 signalling, but also by CAMKII and calcineurin, acting on the same target, the transcription factor DAF-16.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

    Margaret Stratton et al.
    Activation of CaMKII holoenzymes triggers the exchange of subunits with other holoenzymes, including unactivated ones, enabling the calcium-independent phosphorylation and activation of new subunits.
    1. Human Biology and Medicine
    2. Neuroscience

    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

    Poh Hui Chia et al.
    A biallelic missense mutation in the highly conserved, neuron-specific kinase CAMK2A abrogates holoenzyme assembly and causes a new inherited neurodevelopmental disease.
    1. Neuroscience

    The functional organization of descending sensory-motor pathways in Drosophila

    Shigehiro Namiki et al.
    Systematic analysis of descending neuron anatomy reveals the basic functional map of descending sensory-motor pathways in flies and provides genetic tools for targeted interrogation of neural circuits.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density

    Ward G Walkup IV et al.
    The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.

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