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    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski, Choya Yoon ... Roman J Giger
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Biochemistry and Chemical Biology

    Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication

    Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Plant Biology

    A virus responds instantly to the presence of the vector on the host and forms transmission morphs

    Alexandre Martinière, Aurélie Bak ... Martin Drucker
    Cauliflower mosaic virus reacts immediately when aphids feed on the host plant, and this boosts its chances of being taken up and transmitted by the insects to a new plant.
    1. Neuroscience

    Structure and function of axo-axonic inhibition

    Casey M Schneider-Mizell, Agnes L Bodor ... Nuno Maçarico da Costa
    Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids

    Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich
    RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

    Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
    Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
    1. Developmental Biology
    2. Neuroscience

    Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons

    Sara J. Knowles, Michael C. Holter ... Jason M. Newbern
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

    Junhao Li, Antonio Pinto-Duarte ... M Margarita Behrens
    Loss of Dnmt3a in excitatory neurons disrupts synaptic morphology and behavior, and triggers the expansion of H3K27me3 binding, suggestive of increased polycomb repression.
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Cancer Biology

    Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

    James Boot, Gabriel Rosser ... Silvia Marino
    A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.
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