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    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Brain Organoids: Getting the right cells

    Bilal Cakir, In-Hyun Park
    Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
    Version of Record
    Insight
    1. Neuroscience

    The functional organization of descending sensory-motor pathways in Drosophila

    Shigehiro Namiki, Michael H Dickinson ... Gwyneth M Card
    Systematic analysis of descending neuron anatomy reveals the basic functional map of descending sensory-motor pathways in flies and provides genetic tools for targeted interrogation of neural circuits.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    NAIP–NLRC4-deficient mice are susceptible to shigellosis

    Patrick S Mitchell, Justin L Roncaioli ... Russell E Vance
    The NAIP-NLRC4 inflammasome in intestinal epithelial cells protects mice from oral route Shigella infection.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

    Alicia Tapias, David Lázaro ... Zhao-Qi Wang
    The Trrap-HAT-Sp1 axis operates a conserved transcriptional program to control proper microtubule dynamics in brain homeostasis and prevents neurodegeneration.
    1. Biochemistry and Chemical Biology

    Phase separation-mediated actin bundling by the postsynaptic density condensates

    Xudong Chen, Bowen Jia ... Mingjie Zhang
    Biochemical and cell biology studies reveal that postsynaptic density condensates of neuronal synapses and actin cytoskeletons can directly communicate with each other in a phase separation-dependent manner.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density

    Ward G Walkup IV, Tara L Mastro ... Mary B Kennedy
    The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser, Antonio MA Miranda ... Paul R Riley
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Neuroscience

    Optogenetic activation of visual thalamus generates artificial visual percepts

    Jing Wang, Hamid Azimi ... Gregor Rainer
    The visual thalamus is a promising target for neural prosthetic intervention aimed at the restoration of visual function.
    1. Cell Biology
    2. Medicine

    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

    Yang Guo, Ze-Yan Yu ... Boris Martinac
    The TRPM4 ion channel has been identified as an important component in the causation of mechanical pressure overload-induced pathological left ventricular hypertrophy, which is a powerful predictor of cardiovascular mortality.
    1. Neuroscience

    Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

    Jessica Mitchell, Carlas S Smith ... Scott Waddell
    Specific mRNAs localize to the dendrites of Drosophila mushroom body output neurons.