36 results found
    1. Cell Biology
    2. Neuroscience

    Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

    Naoki Yamawaki, Hande Login ... Asami Tanimura
    Unveiling the circuit organization and functional roles of endopiriform neurons projecting to the ventral CA1.
    1. Neuroscience

    Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms

    Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology

    Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

    Revathi Balasubramanian, Krishnakumar Kizhatil ... Simon WM John
    A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.
    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Neuroscience

    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    Katrina Bartas, May Hui ... Kevin T. Beier
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Genetics and Genomics

    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

    Ann-Kathrin Herzfeldt, Marta Puig Gamez ... Lee Kim Swee
    Loss of membrane-bound ICAM-1, overexpression of soluble ICAM-1 or ILKAP activity in tumor cells induce resistance to antigen-specific cytotoxic T-cell-mediated killing independently from regulating antigen presentation, PD-L1 expression, IFN-γ, or TNF-α responsiveness.
    1. Cell Biology
    2. Developmental Biology

    Transcriptional drifts associated with environmental changes in endothelial cells

    Yalda Afshar, Feyiang Ma ... M Luisa Iruela-Arispe
    Nearly half of the transcriptome is altered when endothelial cells transition in vitro, expression patterns for some genes are regained by exposing cells to shear stress and others through exposure to smooth muscle cells.
    1. Neuroscience

    Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

    Elijah A Petter, Isabella P Fallon ... Henry H Yin
    Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.
    1. Neuroscience

    CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

    Brian D Mueller, Sean A Merrill ... Erik M Jorgensen
    The Caenorhabditis elegans presynapse contains two pools of synaptic vesicles at the active zone, coupled to either neuronal-type or muscle-type calcium channels, and to different docking machinery.
    1. Cancer Biology

    EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

    Haitao Luan, Timothy A Bielecki ... Hamid Band
    Identification of a pro-tumorigenic and pro-metastatic role of EHD2 protein in triple-negative breast cancer (TNBC) through the store-operated calcium entry (SOCE) pathway provides a rationale for potential targeting of EHD2-overexpressing TNBC with SOCE inhibitors.

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