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Experience alters neurotransmitter release from different axonal compartments in different ways, allowing a set of neurons to coherently modulate behavior through diverse actions on multiple downstream circuits.

Identification of a pro-tumorigenic and pro-metastatic role of EHD2 protein in triple-negative breast cancer (TNBC) through the store-operated calcium entry (SOCE) pathway provides a rationale for potential targeting of EHD2-overexpressing TNBC with SOCE inhibitors.

A model for flagellar length control based on calcium influx is rejected based on quantitative measurements in Chlamydomonas cells.

A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.

Comprehensive multi-neuron fluorescence imaging in C. elegans reveals age-associated changes in neuronal activity that include a breakdown of system-wide organization, changes in neuronal frequency dynamics, and a disruption of the balance between excitatory and inhibitory signaling.

The protein UNC-8 is a neuronal activity sensor that triggers the elimination of synapses during development of the nervous system.

Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.

The frontal associative cortex promotes fear learning by non-linearly integrating Gaussian noise in between conditioning trials with the help of basolateral amygdala inputs.

Synapses employ distinct acute and chronic signaling processes in order to maintain physiologically appropriate levels of function.