Hawaiian Caenorhabditis elegans harbor high levels of genetic diversity that might represent the complex patterns of ancestral diversity in the species prior to human influence.

snpc-1.3 specifies male piRNA transcription and is regulated by the sex determination pathway.

HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.

Argonaute proteins directly contact adenosine nucleotides in some miRNA target sites, leading to enhanced repression of the target mRNA.

RNAi screening in planarians finds that inhibition of the TEC-family protein tyrosine kinase tec-1 increases the regeneration of neurons through enhancement of cell survival.

The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.

Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.

Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.

PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.

SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.