101 results found
    1. Chromosomes and Gene Expression

    Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

    Jacob M Vogan, Xiaozhu Zhang ... Kathleen Collins
    The Cajal body chaperone TCAB1 and scaffold protein Coilin are not required for telomerase activity in human cells.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body

    Liping Wang, Yi Ding ... Rosa Lozano-Duran
    The Cajal body is essential for plants to deploy antiviral DNA methylation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of human TERT elements necessary for telomerase recruitment to telomeres

    Jens C Schmidt, Andrew B Dalby, Thomas R Cech
    The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.
    1. Neuroscience

    Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

    Ignacio Rebollo, Anne-Dominique Devauchelle ... Catherine Tallon-Baudry
    Coupling between the gastric rhythm and brain activity at rest reveals a novel resting-state network, characterized by delayed functional connectivity.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells

    Yick W Fong, Jaclyn J Ho ... Robert Tjian
    A previously unrecognized transcriptional coactivator function of the dyskerin ribonucleoprotein complex and its associated small nucleolar RNA has been uncovered and mediates embryonic stem cell-specific transcription.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring

    Martina Riva, Ioana Genescu ... Alessandra Pierani
    The complete elimination of a transient superficial population of neurons, and associated immature circuits, is required for the emergence of functional properties in the mature cerebral cortex.
    1. Plant Biology

    Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

    Xiao-Dong Fang, Qiang Gao ... Xian-Bing Wang
    Liquid-liquid phase separation of a rhabovirus phosphoprotein initiates viral factory formation of barley yellow striate mosaic virus, a plant negative-sense RNA virus, and host casein kinase 1-mediated phosphorylation inhibits phase separation and virus infection.
    1. Neuroscience

    Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons

    Kenneth A Pelkey, Daniela Calvigioni ... Chris J McBain
    Glutamate cotransmission from a subset of cortical GABAergic interneurons can promote network hyperexcitability.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker, Wesley A Leigh ... Kenton M Sanders
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Neuroscience

    An inhibitory corticostriatal pathway

    Crystal Rock, Hector Zurita ... Alfonso junior Apicella
    The discovery of somatostatin-positive inhibitory neurons projecting from mouse cortex to striatum shows that corticostriatal pathways are not exclusively excitatory.

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