24 results found
    1. Developmental Biology
    2. Neuroscience

    Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

    Amir Rattner, Chantelle E Terrillion ... Jeremy Nathans
    A mouse mutant in which nearly all dentate gyrus granule cells fail to develop provides a new window on the role of the dentate gyrus in spatial learning and memory.
    1. Neuroscience

    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

    Achira Roy, Rory M Murphy ... Kathleen J Millen
    Embryonic PI3K-Yap activity regulates apical adhesion and proliferation of neural progenitors lining the lateral ventricular surface, to maintain the smooth, non-folded mouse brain and to prevent developmental hydrocephalus.
    1. Neuroscience

    A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types

    Yasuyuki Shima, Ken Sugino ... Sacha B Nelson
    A novel transposon-based enhancer trap screen in mice permits high throughput development of highly restricted driver strains targeting specific neuronal cell types.
    1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi ... Joachim HR Lübke
    Revised
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    1. Developmental Biology
    2. Neuroscience

    Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

    Youngshik Choe, Trung Huynh, Samuel J Pleasure
    During development the Sonic Hedgehog protein is produced by epithelial structures and acts at a distance in the brain and perhaps in other organs.
    1. Developmental Biology
    2. Neuroscience

    Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth

    Parthiv Haldipur, Gwendolyn S Gillies ... Kathleen J Millen
    The mesenchyme surrounding the developing brain plays a significant role in controlling the fundamental growth and patterning of the cerebellum, and misregulation of this signalling can lead to important neurodevelopmental disorders.
    1. Neuroscience

    Dystroglycan is a scaffold for extracellular axon guidance decisions

    L Bailey Lindenmaier, Nicolas Parmentier ... Kevin M Wright
    Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons

    Ayumu Mubuchi, Mina Takechi ... Shinji Miyata
    The extracellular matrix formed during embryonic brain development facilitates the migration of cortical neurons.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of sequentially generated septal neuron fates

    Miguel Turrero García, Sarah K Stegmann ... Corey C Harwell
    A combination of single-cell RNA sequencing of the developing septum and genetic fate mapping is used to analyze the origin of septal neurons.
    1. Developmental Biology
    2. Neuroscience

    Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

    Branden R Nelson, Rebecca D Hodge ... Robert F Hevner
    Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.

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