Molecular genetics identifies a novel microglial pathway essential for mouse brain development and a previously unknown anti-inflammatory activity of monomeric amyloid β that activates this pathway.
A single-nucleus transcriptomic atlas reveals the molecular signatures and trajectory dynamics of the neurogenic lineage in the human hippocampus during neonatal development, adulthood, aging, and after injury.
Branden R Nelson, Rebecca D Hodge ... Robert F Hevner
Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.
L Bailey Lindenmaier, Nicolas Parmentier ... Kevin M Wright
Dystroglycan interacts with multiple partners, including the transmembrane receptor Celsr3, to regulate axon tract formation throughout the developing nervous system.
Parthiv Haldipur, Gwendolyn S Gillies ... Kathleen J Millen
The mesenchyme surrounding the developing brain plays a significant role in controlling the fundamental growth and patterning of the cerebellum, and misregulation of this signalling can lead to important neurodevelopmental disorders.