Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
The combination of high-speed light sheet microscopy and suitable data analysis facilitates cell-accurate measurements across entire organs and opens the way to systematic, scale-bridging, in vivo studies of organogenesis.
Genetic mouse models identify a critical mechanism of myogenic vasoconstriction and reveal the in vivo function of myogenic autoregulation in protecting from organ overperfusion and in maintaining vascular resistance.
Cardiomyocyte Nox4 is a crucial physiological mediator of Nrf2 activation during acute exercise, triggering an adaptive response that preserves redox balance, mitochondrial and cardiac function to support normal physical exercise.
The cerebral cavernous malformations complex is controlled in a blood-flow sensitive manner and affects cardiac valve leaflet morphogenesis by regulating the expression of Klf2 and of Notch signalling activity.
A specialized conduction pathway for the electrical impulse in the heart, previously thought to be associated with the endothermic mammals and birds only, is also present in the ectothermic crocodiles.