171 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

    Rupamanjari Majumder et al.
    Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

    Shanshan Ai et al.
    During heart maturation, embryonic ectoderm development as a chromatin remodeler triggers transcriptional silencing, while H3K27me3 is a passenger that is not sufficient for gene silencing.
    1. Cancer Biology
    2. Medicine

    A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis

    Ming Chao et al.
    Local infusion of bicarbonate into hepatocellular carcinoma markedly enhances local tumor control by transarterial chemoembolization.
    1. Medicine

    Lipocalin-2 is an anorexigenic signal in primates

    Peristera-Ioanna Petropoulou et al.
    Lipocalin-2 is a strong predictor of hunger scores, reflects an anti-obesity response that is deregulated in severely obese subjects, and exerts an anorexigenic function with a conserved interspecies mechanism.
    1. Developmental Biology

    Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

    Lincoln T Shenje et al.
    Cardiac progenitors remain undifferentiated and expansive in the second pharyngeal arch that serves as a microenvironment, and Numb and Numblike are required for their renewal.
    1. Medicine

    Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

    Marlies P Noz et al.
    In patients with coronary artery disease, bone marrow myeloid progenitor cells are reprogrammed towards myeloid skewing and inflammatory activation.
    1. Developmental Biology

    Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography

    Yifu Ding et al.
    X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

    Rupamanjari Majumder et al.
    Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.
    1. Neuroscience

    Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing

    Aravindakshan Parthasarathy et al.
    Ear canal EEG and pupillometry reveal disordered temporal processing in adults with normal hearing who struggle to understand conversations in noisy backgrounds.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: Exploiting natural regulation

    Catherine Proenza
    Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .
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