Preventing premature interactions between microtubules and protein-based structures called kinetochores ensures that chromosomes are segregated by meiosis rather than mitosis in reproductive cells.

Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.

Cells that give rise to the infectious form of parasitic flatworms called schistosomes show similar patterns of gene expression to stem cells in free-living flatworms.

New insights into the assembly and membrane interactions of the caveolar coat complex reveal the reversible association/dissociation of distinct subcomplexes onto the membrane, which differs from the assembly/disassembly of clathrin-coated pits.

Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.

HIV-1 viral protein u (Vpu) can stimulate novel versions of canonical interactions with the clathrin adaptor AP1 to counteract the host antiviral protein BST2.

Overcoming image-processing problems in the analysis of the ClpB chaperone provides a new structural model and regulatory mechanism, based on clear density for the coiled-coil domain and supported by various biochemical data.

The mitotic chromosome periphery is organised by the PP1 binding protein Ki-67 and contributes to nucleolar re-activation upon mitotic exit.

Maternal embryonic leucine zipper kinase (MELK) is a new anti-cancer target that is highly selective for basal-like breast cancer.

The F-box protein Fbxl7 is a direct effector of the protocadherin Fat and functions in downstream pathways that regulate tissue shape and size.