Keith J Mickolajczyk, Paul Dominic B Olinares ... Tarun M Kapoor
The MIDAS domain of Mdn1, an ATP-driven mechanoenzyme involved in ribosome biogenesis, forms catch bonds with two different ubiquitin-like domain-containing ribosomal assembly factors.
Deleting the first helix of the α-catenin actin-binding domain results in a slip bond interaction between the cadherin–catenin complex and F-actin, such that the binding interaction is stable at low force.
A molecular mechanism for force-dependent binding of the cell adhesion proteins αE-catenin and vinculin to actin is derived from the structure of the αE-catenin actin-binding domain bound to F-actin.
Beatriz A Osuna, Conor J Howard ... David E Weinberg
Yeast extracts recapitulate a quality-control pathway dedicated to rescuing stalled ribosomes, providing unexpected insights into a noncanonical elongation reaction and the fate of incompletely synthesized proteins.
Posterior parietal cortex provides an estimation of the location of an object with respect to the body and uses this information to plan appropriate gait changes to negotiate such an obstacle.
Eduard Ort, Johannes Jacobus Fahrenfort ... Christian NL Olivers
During search for multiple targets, individuals can efficiently prepare to select multiple target objects simultaneously, but the actual selection of those objects from the sensory input is limited.
Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
Restoring locomotion after complete spinal cord injury does not require locomotor training, only the return of sufficient excitability within neurons of the spinal cord.
