The ubiquitin ligase c-Cbl preferentially targets unique-region phosphorylated LynA for rapid degradation, regulating its expression and differentially tuning signaling responsiveness in macrophages and mast cells.

Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.

Orphan nuclear receptor Nur77 protects bone by enabling a timely termination of osteoclast differentiation.

Scaffolding protein RAPSYN can exert its NEDD8 E3 ligase activity to neddylate and stabilize oncogenic BCR-ABL by competing proteasomal degradation in Ph⁺ leukemia.

HGF-MET signaling phosphorylates- and PTPRK dephosphorylates ZNRF3 to regulate ZNRF3 internalization, functioning as a rheostat for Wnt signaling.

Base editors, with improved specificity and expanded PAM sequence recognition, can be used in zebrafish for the rapid and efficient introduction of single base pair mutations.

UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.

Genetic and molecular analysis shows that Deltex modulates the Wingless gradient and counters Wingless signaling by promoting Armadillo/β-catenin degradation through a conserved regulatory mechanism.

DDB1, a component of the ubiquitin proteasome system, plays a role in both hematopoietic and embryonic stem cell self-renewal and differentiation.