1,304 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

    Xiaoxiao Li et al.
    Orphan nuclear receptor Nur77 protects bone by enabling a timely termination of osteoclast differentiation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

    Daniela Justa-Schuch et al.
    Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
    1. Plant Biology

    Correction: A tension-adhesion feedback loop in plant epidermis

    Stéphane Verger et al.
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau et al.
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Microbiology and Infectious Disease

    Symbiosis: Breaking down walls to live in harmony

    Natalia Requena, Reinhard Fischer
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  1. Research: United States National Postdoc Survey results and the interaction of gender, career choice and mentor impact

    Sean C McConnell et al.
    The quality of mentoring received while a postdoc influences career choice irrespective of field, gender, or ethnicity, according to a 7,603-respondent postdoc survey.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.

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