56 results found
    1. Cell Biology
    2. Neuroscience

    Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

    Jinye Dai, Kif Liakath-Ali ... Thomas C Südhof
    A genetic manipulation of the Nrxn1/3SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.
    1. Cell Biology
    2. Neuroscience

    An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus

    Thi-Minh Nguyen, Dietmar Schreiner ... Peter Scheiffele
    Interneuron-specific alternative splice variants of the synaptic receptor neurexin are critical for hippocampal network activity and short-term memory.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie, Mengdi Wang ... Xiaoqun Wang
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.
    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek, Elisabeth Gueydon, Etienne Schwob
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    1. Cell Biology

    Reliable cell cycle commitment in budding yeast is ensured by signal integration

    Xili Liu, Xin Wang ... Chao Tang
    The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.
    1. Neuroscience

    The subiculum is a patchwork of discrete subregions

    Mark S Cembrowski, Lihua Wang ... Nelson Spruston
    Pyramidal cells of the subiculum, a major output cell type of the hippocampus, can be deconstructed into distinct subtypes that exhibit a patchwork-like organization in space.
    1. Chromosomes and Gene Expression

    Control of meiotic entry by dual inhibition of a key mitotic transcription factor

    Amanda J Su, Siri C Yendluri, Elçin Ünal
    Investigation of how cells rewire their transcriptional programs during transition from mitotic to meiotic cell fate reveals a two-pronged mechanism for inactivating a key mitotic transcription factor.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

    Edgar M Medina, Jonathan J Turner ... Nicolas E Buchler
    Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
    1. Neuroscience

    Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

    Zhihui Liu, Man Jiang ... Thomas C Südhof
    Calsyntenin-3 functions in cerebellar Purkinje neurons as a postsynaptic adhesion molecule that, unexpectedly, suppresses excitatory parallel-fiber synapse numbers but boosts inhibitory synapse numbers and thereby controls the excitatory/inhibitory balance of Purkinje neurons.

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