1,590 results found
    1. Cell Biology
    2. Developmental Biology

    Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

    Nuno Costa-Borges et al.
    Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.
    1. Cell Biology

    Bmal1 integrates mitochondrial metabolism and macrophage activation

    Ryan K Alexander et al.
    Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.
    1. Chromosomes and Gene Expression

    Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

    Anand Ranjan et al.
    Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
    1. Developmental Biology

    Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates

    Tempei Sato et al.
    Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.
    1. Neuroscience

    Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

    Alexandra N Trelle et al.
    The strength of pattern completion during memory retrieval, indexed by hippocampal activity and cortical reinstatement, explains within- and across-individual variability in episodic memory in older adults.
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang et al.
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

    Eran Mick et al.
    Mitochondrial electron transport chain dysfunction triggers the integrated stress response due to an asparagine deficiency downstream of impaired NADH oxidation in proliferating myoblasts, but not in differentiated myotubes.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Identifying the immune interactions underlying HLA class I disease associations

    Bisrat J Debebe et al.
    HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
    1. Cell Biology
    2. Human Biology and Medicine

    Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2

    Adela Constantinescu-Bercu et al.
    The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.

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