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    1. Cell Biology

    Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

    Olga Afonso et al.
    Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
    1. Cancer Biology
    2. Cell Biology

    The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

    Shaheen Kabir et al.
    Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
    1. Cancer Biology

    Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

    Mei Zeng et al.
    A multi-transcriptional CDKs inhibitor suppresses MYC and induces regression of ovarian tumors, indicating that targeting CDK7, 12, 13 with THZ1 may be an effective approach for treating MYC-dependent malignancies.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

    Cécile Alanio et al.
    Naïve CD8+ T cells are dysregulated during chronic hepatitis C (HCV) infection, and this is reversible after viral clearance.
    1. Immunology and Inflammation

    Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

    Neha R Deshpande et al.
    Higher affinity for self-pMHC complexes and broader promiscuity for foreign-pMHC complexes imparts a fitness advantage within the CD4+ T cell compartment in older mice.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytotoxic activities of CD8+ T cells collaborate with macrophages to protect against blood-stage murine malaria

    Takashi Imai et al.
    The cytotoxicity exerted by CD8+ T cells against parasitized erythroblasts helps to protect against blood-stage malaria by making parasitized cells susceptible to phagocytosis.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova et al.
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Chromosomes and Gene Expression

    The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

    Adrien Birot et al.
    Cohesin loader activity is regulated by phosphorylation of its cohesin substrate.
    1. Immunology and Inflammation

    HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

    Rachael Laura Philips et al.
    CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz et al.
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.