658 results found
    1. Cell Biology

    Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

    Olga Afonso et al.
    Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
    1. Cell Biology

    Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

    Ana Maria G Dumitru et al.
    Quantitative phosphoproteomics defines the substrates for Cyclin A/Cdk1 kinase during early mitosis and follow up studies validate that one identified substrate, MYPT1, influences the stability of k-MT attachments by regulating Plk1.
    1. Biochemistry and Chemical Biology

    A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

    Katherine J Susa et al.
    The tetraspanin CD81 uses its ectodomain to export CD19, and the interaction of the two proteins is dynamically regulated by B cell activation state.
    1. Chromosomes and Gene Expression

    Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

    Madhusudhan Srinivasan et al.
    In G1 cells, Scc2 loads and maintains cohesin on chromosomes by counteracting a Wapl-independent releasing activity, which is neutralized in S phase by CDK1.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Chromosomes and Gene Expression

    High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    Douglas Maya Miles et al.
    Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.
    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek et al.
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    1. Cell Biology

    DNA Replication: Rethinking origin licensing

    Stephen P Bell
    Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
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    1. Biochemistry and Chemical Biology

    Intracellular Organization: Getting ready for DNA duplication

    Nina Y Yao, Michael E O'Donnell
    The discovery of a biomolecular condensate involved in DNA replication has wide ranging implications.
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    1. Immunology and Inflammation

    Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

    Jie Zhao et al.
    A humanized transgenic mouse model reveals that CD1b-restricted, mycolic acid-specific T cells play a protective role during Mycobacterium tuberculosis infection.

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