2,383 results found
    1. Cell Biology
    2. Developmental Biology

    Tgfβ signaling is critical for maintenance of the tendon cell fate

    Guak-Kim Tan et al.
    Conditional deletion of TGFβ signaling results in tenocyte dedifferentiation in vivo demonstrating a key role for TGFβ signaling in the maintenance of the tendon cell fate.
    1. Developmental Biology

    Epigenetic regulation of hematopoiesis by DNA methylation

    Aniket V Gore et al.
    Methylation of a key transcription factor gene by a de novo DNA methyltransferase assures the maintenance of hematopoietic stem cell fate.
    1. Developmental Biology

    NOTCH activity differentially affects alternative cell fate acquisition and maintenance

    Leonard Cheung et al.
    Activation of NOTCH signalling in different cell lineages of the embryonic murine pituitary uncovers an unexpected differential sensitivity, and this consequently reveals new aspects of endocrine lineages development and plasticity.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

    Yul W Yang et al.
    RNA binding is a key input of an active chromatin complex and maintenance of stem cell fate.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.
    1. Microbiology and Infectious Disease

    HIV in Women: How HIV exploits T cells in the endometrium

    Marta Rodriguez-Garcia
    Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Phenotypic Diversity: Setting the bar

    Charles Y Feigin, Ricardo Mallarino
    Analyzing the genomes of rock pigeons demonstrates that genetic variation comes in many forms and can have unexpected origins.
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    1. Stem Cells and Regenerative Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
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    1. Stem Cells and Regenerative Medicine

    Stem Cells: What silent mutations say about the human airways

    Matthew L Donne, Jason R Rock
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