Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.

The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.

Novel segmental chromosome amplifications in Candida albicans provide rapid adaptation to the most widely used antifungal drugs.

Proximity and homology guided inter-chromosomal translocations drive karyotype evolution.

Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.

A putative histone demethylase in fission yeast has non-enzymatic properties that regulates heterochromatin assembly and epigenetic inheritance.

Centromere deletion in Cryptococcus deuterogattii results in neocentromeres, which span actively expressed genes and at elevated temperatures cen10∆ mutants are unstable leading to chromosome fusion and silencing of the neocentromere.

A ménàge à trois introduces extra DNA only to plant embryos, thus skipping endosperm-induced seed hybridization barriers.

De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.

Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.