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    1. Developmental Biology

    A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms

    Hadi Boukhatmi, Sarah Bray
    Adult muscle progenitors evade differentiation by expressing a short RNA isoform of Zfh1 which is insensitive to regulation by a micro-RNA.
    1. Chromosomes and Gene Expression

    A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

    Chun-Min Shan et al.
    A lysine-to-methionine mutation in histone H3 dominantly blocks histone H3K9 methylation by trapping its methyltransferase.
    1. Chromosomes and Gene Expression

    Distinct ‘safe zones’ at the nuclear envelope ensure robust replication of heterochromatic chromosome regions

    Hani Ebrahimi et al.
    The nuclear periphery houses compositionally and functionally distinct domains, one of which provides a 'safe zone' for replication and reassembly of heterochromatic genome regions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski et al.
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome plasticity in Candida albicans is driven by long repeat sequences

    Robert T Todd et al.
    Previously uncharacterized long repeat sequences are associated with significant genome variation that can increase fitness and promote antifungal drug resistance in diverse isolates of Candida albicans.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Dynamic turnover of centromeres drives karyotype evolution in Drosophila

    Ryan Bracewell et al.
    De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Ndc80 complex bridges two Dam1 complex rings

    Jae ook Kim et al.
    The ability of the Ndc80 complex to bind two Dam1 complex rings is important for chromosome attachment, and the distance between the two rings is vital for supporting growth.
    1. Neuroscience

    A long non-coding RNA is required for targeting centromeric protein A to the human centromere

    Delphine Quénet, Yamini Dalal
    A non-coding RNA-based targeting mechanism could potentially epigenetically maintain specialized chromatin structures, such as the centromere, in vivo.
    1. Chromosomes and Gene Expression

    Cohesin architecture and clustering in vivo

    Siheng Xiang, Douglas Koshland
    Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs

    Robert T Todd, Anna Selmecki
    Novel segmental chromosome amplifications in Candida albicans provide rapid adaptation to the most widely used antifungal drugs.