15,430 results found
    1. Cancer Biology
    2. Epidemiology and Global Health

    Disentangling the relationship between cancer mortality and COVID-19 in the US

    Chelsea L Hansen, Cécile Viboud, Lone Simonsen
    The competing mortality risk from cancer itself overshadows any increase in COVID-19 mortality risk due to cancer.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham, Benjamin E Wolfe, Rachel J Dutton
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of opening and closing of the bacterial replicative helicase

    Jillian Chase, Andrew Catalano ... David Jeruzalmi
    Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese, Katia S Chadaideh ... Rachel N Carmody
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Microbiology and Infectious Disease

    Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut

    Aspen T Reese, Eugenia H Cho ... Lawrence A David
    Disturbing the microbiota with antibiotics alters gut redox state via changes in electron acceptor availability, setting the stage for post-antibiotic succession.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reactive oxygen species oxidize STING and suppress interferon production

    Lili Tao, Andrew Lemoff ... Tiffany A Reese
    Redox modification of STING represents a novel target for interferon regulation and control of herpesvirus replication.
    1. Plant Biology

    Uncovering natural variation in root system architecture and growth dynamics using a robotics-assisted phenomics platform

    Therese LaRue, Heike Lindner ... José R Dinneny
    Advances in robotics-assisted plant handling and automated image analysis enables the characterization of root growth dynamics for Arabidopsis accessions at late stages of development and the association of these traits with genetic variation and climatic variables.
    1. Computational and Systems Biology
    2. Neuroscience

    Dynamic range adaptation in primary motor cortical populations

    Robert G Rasmussen, Andrew Schwartz, Steven M Chase
    Motor neurons adjust their sensitivity to direction of movement in a manner analogous to how neurons in the visual system adjust their sensitivity to light.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

    Chase A Weidmann, Chen Qiu ... Aaron C Goldstrohm
    Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
    1. Neuroscience

    Constraints on neural redundancy

    Jay A Hennig, Matthew D Golub ... Steven M Chase
    The distribution of redundant neural activity is coupled with task-relevant activity, which may limit the extent to which redundancy can be exploited by the brain for computation.

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