With mathematical modeling being an important source of insight for microbial communities, we may need to move beyond commonly-used pairwise models that do not capture microbial interactions.
Susanne Müller, Suzanne Ackloo ... Anke Mueller-Fahrnow
A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.
Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.
Stella Reichling, Peter F Doubleday ... Duncan Holbrook-Smith
High throughput metabolome profiling of yeast cells that are dynamically perturbed with the drug rapamycin can be used to implicate new genes in the key cellular process of TOR signaling, including the gene of unknown function CFF1.
Hannes Mutschler, Alexander I Taylor ... Philipp Holliger
Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
Nilkanth Patel, Xi Ping Huang ... Vsevolod Katritch
Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.
