1,593 results found
    1. Evolutionary Biology
    2. Plant Biology

    An unexpected noncarpellate epigynous flower from the Jurassic of China

    Qiang Fu et al.
    Flowers did bloom in the Early Jurassic.
    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia et al.
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cohesin mutations are synthetic lethal with stimulation of WNT signaling

    Chue Vin Chin et al.
    Hypersensitivity of cohesin-deficient cells to Wnt signaling is concomitant with beta catenin stabilization and offers promise that Wnt agonists could be therapeutically effective in cohesin mutant cancers.
    1. Cell Biology

    ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration

    Joanne Chia et al.
    The ERK8 kinase blocks the export of glycosyl-tranferases from the Golgi to the endoplasmic reticulum, and thus subsequent O-glycosylation of proteins that otherwise enhance cell motility and tissue invasion.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

    Jiahui Si et al.
    Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
    1. Evolutionary Biology

    Birds land reliably on complex surfaces by adapting their foot-surface interactions upon contact

    William RT Roderick et al.
    When landing, Pacific parrotlets exhibit stereotyped leg and wing dynamics regardless of perch diameter and texture, but foot and claw kinematics become surface-specific upon touchdown to successfully grasp the perch.
    1. Immunology and Inflammation

    Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

    Shiho Chiba et al.
    An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.
    1. Evolutionary Biology

    How oscillating aerodynamic forces explain the timbre of the hummingbird’s hum and other animals in flapping flight

    Ben J Hightower et al.
    A first-principles acoustics model reveals how the acoustic spectrum generated by flapping wings originates from oscillating aerodynamic forces, and is validated by in vivo aerodynamic force measurements and acoustic holography.
    1. Neuroscience

    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

    Poh Hui Chia et al.
    A biallelic missense mutation in the highly conserved, neuron-specific kinase CAMK2A abrogates holoenzyme assembly and causes a new inherited neurodevelopmental disease.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Cancer-associated TERT promoter mutations abrogate telomerase silencing

    Kunitoshi Chiba et al.
    TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.

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