200 results found
    1. Developmental Biology

    Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila

    Amrutha Kizhedathu et al.
    ATR/Chk1 contribute to G2 arrest in developing tracheoblasts, and arrest in G2 facilitates cellular and hypertrophic organ growth.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

    Victor Ovchinnikov et al.
    Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles

    Franziska Decker et al.
    Quantitative microscopy and theory show that the size of Xenopus laevis egg extract spindles is controlled by a spatially-regulated autocatalytic growth mechanism driven by microtubule-stimulated microtubule nucleation.
    1. Cell Biology

    Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation

    Saralin Davis et al.
    Phosphorylation of a core trafficking component, the COPII coat subunit Sec24, regulates cross-talk between the secretory and autophagy machinery during starvation.
    1. Developmental Biology

    Compartmentalized oskar degradation in the germ plasm safeguards germline development

    Catherine E Eichler et al.
    RNP granules confer temporal and spatial regulation of oskar mRNA degradation to minimize inheritance of oskar mRNAby germ cells and thereby protect germline development.
    1. Cell Biology
    2. Plant Biology

    Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants

    Madhumitha Narasimhan et al.
    The examination of the ultra-structure and in vivo dynamics of endocytosis in plants reveal plants unique actin-independent, clathrin-mediated endocytosis mechanisms to overcome their unique physiological properties.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk et al.
    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush et al.
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Cell Biology

    Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry

    Corey A H Allard et al.
    Dynamic signaling protein clusters sample and map the cell surface to ensure that cells divide at the proper size.

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