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The Natural History of Model Organisms: An organismal perspective on
development, origins and diversification
Matthew J Kourakis, William C Smith
The life cycle and morphology of the sea squirt
shed light on vertebrate evolution.
Paleontology: These feet were made for walking
William L Jungers
Point of View: Basic research at the epicenter of an epidemic
William R Bishai
William R Bishai, director of the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), argues that the best place to carry out research into a disease is in its midst.
Genetics and Genomics
Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence
Diane Marie Keeling et al.
A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.
Meta-Research: Why we need to report more than 'Data were Analyzed by t-tests or ANOVA'
Tracey L Weissgerber et al.
Many papers in basic biomedical science do not contain the information that is needed to determine what statistical tests were used and to verify the results of these tests.
Ophthalmology: Keeping blood vessels out of sight
Dawn Sim, Marcus Fruttiger
Physics of Living Systems
Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Kaushikaram Subramanian et al.
Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure
Sarah Jacquelyn Smith et al.
A new morphological structure evolved through extreme changes in cell height requires novel connections to an extracellular matrix network, which predates the origin of structure.
Revisiting the role of Dcc in visual system development with a novel eye clearing method
Robin J Vigouroux et al.
A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data
Samuel A Neymotin et al.
Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
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