40 results found
    1. Neuroscience

    Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

    Keming Zhou et al.
    The precise position of UNC-13 at the active zone near a synapse depends on the N-terminus of the protein, and the C2A domain in particular, and is essential for accelerating neurotransmitter release.
    1. Developmental Biology
    2. Evolutionary Biology

    Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment

    Kate A Rawlinson et al.
    A new opsin receptor is light-sensitive and expressed in a unique type of photoreceptor in a flatworm that encloses over 400 sensory cilia within its cell membrane.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode et al.
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
    1. Physics of Living Systems

    Upper bound on the biological effects of 50/60 Hz magnetic fields mediated by radical pairs

    PJ Hore
    Any effects of environmental 50/60 Hz magnetic fields on human biology due to a radical pair mechanism should be no more dangerous than those incurred by travelling a few kilometres.
    1. Cell Biology

    The cell proliferation antigen Ki-67 organises heterochromatin

    Michal Sobecki et al.
    Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
    1. Human Biology and Medicine
    2. Neuroscience

    A Cryptochrome 2 mutation yields advanced sleep phase in humans

    Arisa Hirano et al.
    A missense mutation in the human Cryptochrome 2 (CRY2) gene leads to the condition of familial advanced sleep phase.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Neuroscience

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons

    Jason D Vevea, Edwin R Chapman
    Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
    1. Neuroscience

    The impact of bilateral ongoing activity on evoked responses in mouse cortex

    Daisuke Shimaoka et al.
    Spontaneous bilateral fluctuations add with evoked cortical activity and explain much of the variability in sensory responses.
    1. Neuroscience

    Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

    Romain Durand-de Cuttoli et al.
    In vivo deconstruction of reward-related behaviors with circuit and pharmacological specificity using designer, light-controllable nicotinic acetylcholine receptors.

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