780 results found
    1. Cell Biology
    2. Developmental Biology

    Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

    Jamie C Little et al.
    Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.
    1. Microbiology and Infectious Disease

    Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses

    Ci-Xiu Li et al.
    Extensive genetic diversity and novel genome structures in RNA viruses from arthropods shed important new light on the ancestry and evolutionary history of major classes of vertebrate and plant viruses.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors

    John Frederick Beckmann et al.
    Genetic and proteomic screening with Wolbachia's CidB enzyme reveal the mechanisms and targets of cytoplasmic incompatibility (CI).
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: what have we learned in 50 years?

    J Dylan Shropshire et al.
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Structural Biology and Molecular Biophysics

    The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

    Akira Kawanabe et al.
    Electrophysiological and fluorometric studies of Ci-VSP expressed in Xenopus oocyte revealed two states of the enzyme region with distinct enzyme activity and distinct coupling to the voltage sensor.
    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.

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