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Genetics and Genomics
An integrative study of five biological clocks in somatic and mental health
Rick Jansen et al.
An integrative study of five biological clocks in somatic and mental health indicate that one's biological age is best reflected by combining aging measures from multiple cellular levels.
TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin
Fernando R Balestra et al.
TRIM37 prevents the formation of centriolar protein assemblies through an atypical de novo assembly pathway that would otherwise threaten genome integrity.
Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain
Sweta Parab et al.
Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.
Genetics and Genomics
Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of
Chanhyun Park et al.
A ClC chloride channel protein allows neurons to interpret both temporal resolution and intensity of sensory input, which thereby contributes to an experience-dependent navigation behavior.
Biochemistry and Chemical Biology
ARL3 activation requires the co-GEF BART and effector-mediated turnover
Yasmin ElMaghloob et al.
BART is a co-GEF for ARL3 and maintains the active ARL3-GTP until it is recycled by ARL3 effectors.
Dentate gyrus development requires a cortical hem-derived astrocytic scaffold
Alessia Caramello et al.
An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.
Microbiology and Infectious Disease
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
Anna Z Mykytyn et al.
Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models
Kyeong-Hye Moon et al.
Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
Chanjae Lee et al.
DynAPs are liquid-like organelles that are partitioned into functional sub-domains.
-glycan composition impacts flagella-mediated adhesion in
Nannan Xu et al.
Adhesion force measurements reveal that proper
-glycosylation of flagellar membrane proteins is crucial for adhering
cells onto surfaces.
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